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Using similar strategies for upstream positive regulators of GPX4, for example, upregulating SLC7A11 expression via gene therapy, can multi-targetedly enhance the cells overall antioxidant capacity and GSH supply, thereby indirectly supporting and enhancing GPX4 activity (Liao et al., 2024)

Barna L, Walter FR, Harazin A, Bocsik A, Kincses A, Tubak V, et al

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Vagus nerve toning using vagal nerve stimulation and/or exercises help support parasympathetic dominance, enabling the body to counter cortisol levels and effectively releasing stress from the cells, promoting relaxation, sleep and digestion